Characteristics of familial aggregation in early‐onset Alzheimer's disease: Evidence of subgroups
Identifieur interne : 000266 ( France/Analysis ); précédent : 000265; suivant : 000267Characteristics of familial aggregation in early‐onset Alzheimer's disease: Evidence of subgroups
Auteurs : Campion [France] ; M. Martinez [France] ; D. Hannequin ; A. Brice [France] ; C. Thomas-Anterion [France] ; A. Michon [France] ; M. C. Babron [France] ; B. Dubois [France] ; Y. Goas [France] ; A. Jaillard-Serradt [France] ; F. Ledoze [France] ; F. Pasquier [France] ; M. Puel [France] ; M. A. Zimmerman [France] ; M. Bellis [France] ; J. Mallet [France] ; Yves Agid [France] ; F. Clerget-Darpoux [France]Source :
- American Journal of Medical Genetics [ 0148-7299 ] ; 1995-06-19.
English descriptors
- KwdEn :
Abstract
Characteristics of familial aggregation of Alzheimer's Disease were studied in 92 families ascertained through a clinically diagnosed proband with an onset below age 60 years. In each family data were systematically collected on the sibships of the proband, of his father, and of his mother. A total of 926 relatives were included and 81% of the living relatives (i.e., 251 individuals) were directly examined. The estimated cumulative risk among first degree relatives was equal to 35% by age 89 years (95% confidence interval 22 to 47%). This result does not support the hypothesis that an autosomal dominant gene, fully penetrant by age 90 years, is segregating within all these pedigrees. Despite the fact that all probands were selected for an onset before age 60 years it was shown that two types of families could be delineated with respect to age at onset among affected relatives: all secondary cases with an onset below age 60 years were contributed by a particular group of families (type 1 families), whereas all secondary cases with an onset after age 60 years were contributed by another group of families (type 2 families). Although genetic interpretation of these findings is not straightforward, they support the hypothesis of etiologic heterogeneity in the determinism of early‐onset Alzheimer's disease. © 1995 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.1320600310
Affiliations:
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Genet.</title><idno type="ISSN">0148-7299</idno><idno type="eISSN">1096-8628</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1995-06-19">1995-06-19</date><biblScope unit="volume">60</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="221">221</biblScope><biblScope unit="page" to="227">227</biblScope></imprint><idno type="ISSN">0148-7299</idno></series><idno type="istex">C9095FC80509EA62229B8B65A39BF027903D3B8C</idno><idno type="DOI">10.1002/ajmg.1320600310</idno><idno type="ArticleID">AJMG1320600310</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0148-7299</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's disease</term><term>early onset</term><term>morbid risk</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Characteristics of familial aggregation of Alzheimer's Disease were studied in 92 families ascertained through a clinically diagnosed proband with an onset below age 60 years. In each family data were systematically collected on the sibships of the proband, of his father, and of his mother. A total of 926 relatives were included and 81% of the living relatives (i.e., 251 individuals) were directly examined. The estimated cumulative risk among first degree relatives was equal to 35% by age 89 years (95% confidence interval 22 to 47%). This result does not support the hypothesis that an autosomal dominant gene, fully penetrant by age 90 years, is segregating within all these pedigrees. Despite the fact that all probands were selected for an onset before age 60 years it was shown that two types of families could be delineated with respect to age at onset among affected relatives: all secondary cases with an onset below age 60 years were contributed by a particular group of families (type 1 families), whereas all secondary cases with an onset after age 60 years were contributed by another group of families (type 2 families). Although genetic interpretation of these findings is not straightforward, they support the hypothesis of etiologic heterogeneity in the determinism of early‐onset Alzheimer's disease. © 1995 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Hannequin, D" sort="Hannequin, D" uniqKey="Hannequin D" first="D." last="Hannequin">D. Hannequin</name></noCountry><country name="France"><noRegion><name sortKey="Campion" sort="Campion" uniqKey="Campion" last="Campion">Campion</name></noRegion><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Babron, M C" sort="Babron, M C" uniqKey="Babron M" first="M. C." last="Babron">M. C. Babron</name><name sortKey="Bellis, M" sort="Bellis, M" uniqKey="Bellis M" first="M." last="Bellis">M. Bellis</name><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name><name sortKey="Clerget Arpoux, F" sort="Clerget Arpoux, F" uniqKey="Clerget Arpoux F" first="F." last="Clerget-Darpoux">F. Clerget-Darpoux</name><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><name sortKey="Goas, Y" sort="Goas, Y" uniqKey="Goas Y" first="Y." last="Goas">Y. Goas</name><name sortKey="Jaillard Erradt, A" sort="Jaillard Erradt, A" uniqKey="Jaillard Erradt A" first="A." last="Jaillard-Serradt">A. Jaillard-Serradt</name><name sortKey="Ledoze, F" sort="Ledoze, F" uniqKey="Ledoze F" first="F." last="Ledoze">F. Ledoze</name><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name><name sortKey="Martinez, M" sort="Martinez, M" uniqKey="Martinez M" first="M." last="Martinez">M. Martinez</name><name sortKey="Michon, A" sort="Michon, A" uniqKey="Michon A" first="A." last="Michon">A. Michon</name><name sortKey="Pasquier, F" sort="Pasquier, F" uniqKey="Pasquier F" first="F." last="Pasquier">F. Pasquier</name><name sortKey="Puel, M" sort="Puel, M" uniqKey="Puel M" first="M." last="Puel">M. Puel</name><name sortKey="Thomas Nterion, C" sort="Thomas Nterion, C" uniqKey="Thomas Nterion C" first="C." last="Thomas-Anterion">C. Thomas-Anterion</name><name sortKey="Zimmerman, M A" sort="Zimmerman, M A" uniqKey="Zimmerman M" first="M. A." last="Zimmerman">M. A. Zimmerman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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